Evidence, stated plainly.

PREPRINT · MEDRXIV · JULY 2026

An Evaluation of DMR-Informed Fine-Tuning of Tissue Array–Pretrained CpGPT for Gastrointestinal Cancer Classification Using cfDNA Targeted Methylation

Xu Y, Feng Q. medRxiv, 29 July 2026. doi.org/10.64898/2026.07.26.26358979

Summary

A genomic foundation model fine-tuned on sparse cell-free DNA methylation data, outperforms conventional machine-learning baselines in gastrointestinal cancer classification.